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Platelet Adhesion Proteins and Ligands

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Activated Integrin
alpha 2 beta 1

Activated Integrin
alpha 2b beta 3

Activated Integrin
alpha 5 beta 1

Activated Integrin
alpha 6 beta 1

GPVI

FCER1G

GPIb

GPIX

Glycoprotein V

G6b

CLEC-2

CD36/SR-B3/
GPIIIb

P-Selectin/
CD62P

CD40 Ligand/
TNFSF5

Ligands of Activated
Adhesion Proteins

Collagen

C1q

Decorin

E-Cadherin

Laminin

Fibrinogen

Fibronectin

Plasminogen

Prothrombin

Thrombospondin

Vitronectin

Fibronectin

Laminin

Collagen

Factor XI, XII

Kininogen

P-Selectin

Thrombin

vWF-A2

Heparin

Podoplanin
Rhodocytin

Thrombospondin

PSGL-1/CD162

CD40/TNFRSF5

Extracellular matrix molecules are exposed in damaged vascular endothelium.

Platelet adhesion to endothelium is stabilized by activated integrin binding.

Ligands are expressed on leukocytes.

Adhesion does not require interaction with vasculature.

Interaction promotes leukocyte activation.

Overview of Platelet Adhesion Proteins and Ligands

Platelets adhere to the vascular endothelium at sites of endothelial injury where extracellular matrix (ECM) components in the sub-endothelial space are exposed to the circulation. GP family glycoproteins mediate rapid tethering to ECM molecules at these sites. Integrin heterodimers become activated and then provide robust platelet adhesion. Adhesion is an early phase of platelet activation and limits bleeding by promoting platelet aggregation and clot formation (thrombosis). Circulating molecules, such as vWF-A2 and Thrombospondin also contribute to platelet aggregate formation. In addition, platelets can form circulating aggregates with monocytes and leukocytes to enhance systemic inflammatory responses.

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